Riesgos y beneficios de la hidroxiurea en la prevención de crisis hemolítica en niños con drepanocitosis
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2019
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
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En el Ecuador, según las cifras del Instituto Nacional de estadística y censo (INEC-2012) se estima que en el país hay 1'041.559 habitantes afroecuatorianos que residen en las ciudades de Guayaquil, Esmeralda, Imbabura, Carchi y que dentro de esta población hay 166.649 casos reportados con anemia de células falciforme. Además, se realizó un estudio cohorte donde se estimó que la prevalencia, comprendida entre el año 2000 al 2013 fue aproximadamente uo de cada 12400 pacientes pediátricos que acude a la emergencia del hospital Icaza Bustamante en la ciudad de Guayaquil, con anemia falciforme y que el 56, 93% de los casos corresponde al género masculino. El presente trabajo de investigación tiene como objetivo los riesgos y beneficios de la hidroxiurea en la prevención de crisis hemolítica en los niños con drepanocitosis atendidos en el hospital francisco Icaza Bustamante, período 2014-2017, metodología y población se aplicó un estudio de enfoque cuantitativo, no experimental, de corte transversal y retrospectivo tomando en consideración las bases de datos de 120 niños con anemia drepanocítica, obteniendo como resultados el grupo etario de mayor porcentaje, 53 % de sexo masculino y el 47% del sexo femenino. Los rangos en relación con la estancia hospitalaria en el 2014-2015 de ingreso fue 37% a 29% menos de dos meses mientras que en mayor de 4 meses los ingresos fueron 2016 a 2017 fue 3% a 2% lo que nos indica que se está obteniendo mejor resultados preventivos con la hidroxiurea prologando el período de tiempo hospitalario, disminuyendo los reingresos por trasfusiones sanguíneas y las complicaciones de la misma
In Ecuador, according to figures from the National Institute of statistics and census (INEC-2012) it is estimated that there are 1'041,559 Afro-Ecuadorian inhabitants residing in the cities of Guayaquil, Esmeralda, Imbabura, Carchi and that within this population there are 166,649 cases reported with sickle cell anemia. In addition, a cohort study was carried out where it was estimated that the prevalence between the year 2000 and 2013 was approximately one in 12400 pediatric patients who came to the Icaza Bustamante hospital emergency in the city of Guayaquil with sickle cell anemia and that the 56, 93% of cases correspond to the male gender. The present research work aims at the risks and benefits of hydroxyurea in the prevention of hemolytic crisis in children with sickle cell disease treated at the Icaza Bustamante hospital, 2014-2017 period, methodology and population, a quantitative approach study was applied, non-experimental, cross-sectional and retrospective taking into consideration the data bases of 120 children with sickle-cell anemia, obtaining as a result the age group with the highest percentage, 53% male and 47% female. The ranges in relation to the hospital stay in the 2014-2015 of admission were 37% to 29% less than two months while in more than 4 months the income was 2016 to 2017 was 3% to 2% which indicates that is getting better preventive results with hydroxyurea prolonging the period of hospital time, decreasing re-admissions due to blood transfusions and complications of it
In Ecuador, according to figures from the National Institute of statistics and census (INEC-2012) it is estimated that there are 1'041,559 Afro-Ecuadorian inhabitants residing in the cities of Guayaquil, Esmeralda, Imbabura, Carchi and that within this population there are 166,649 cases reported with sickle cell anemia. In addition, a cohort study was carried out where it was estimated that the prevalence between the year 2000 and 2013 was approximately one in 12400 pediatric patients who came to the Icaza Bustamante hospital emergency in the city of Guayaquil with sickle cell anemia and that the 56, 93% of cases correspond to the male gender. The present research work aims at the risks and benefits of hydroxyurea in the prevention of hemolytic crisis in children with sickle cell disease treated at the Icaza Bustamante hospital, 2014-2017 period, methodology and population, a quantitative approach study was applied, non-experimental, cross-sectional and retrospective taking into consideration the data bases of 120 children with sickle-cell anemia, obtaining as a result the age group with the highest percentage, 53% male and 47% female. The ranges in relation to the hospital stay in the 2014-2015 of admission were 37% to 29% less than two months while in more than 4 months the income was 2016 to 2017 was 3% to 2% which indicates that is getting better preventive results with hydroxyurea prolonging the period of hospital time, decreasing re-admissions due to blood transfusions and complications of it
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HIDROXIUREA, CRISIS DREPANOCITICA, ANEMIA DE CELULAS FALCIFORMES, PEDIATRIA, ESTUDIO RETROSPECTIVOS, HOSPITALES DEL NIÑO FRANCISCO DE ICAZA BUSTAMANTE, CANTON GUAYAQUIL, ECUADOR