Marcadores inflamatorios como factor pronóstico de sepsis en pacientes neutropénicos febriles
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2016
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
Un importante problema de salud, representan las enfermedades oncológicas en todo
el mundo. El problema es evidente en países con recursos limitados debido al aumento
poblacional y el bajo nivel socio-económico. Se estima que el cáncer es la tercera o
cuarta causa de muerte en los de países en desarrollo. El Objetivo general de este estudio
es Evaluar el Uso de Marcadores Inflamatorios como factor pronóstico de Sepsis en
Pacientes Neutropénicos Febriles, que ingresaron a Emergencia de SOLCA en el
periodo 2015, estos pacientes debían cumplir con ciertos criterios clínicos. Se utilizó la
metodología científica y el método fue Descriptivo, Retrospectivo, Transversal no
experimental, con un Universo de 250 pacientes y una muestra de 152. Entre los
resultados obtenidos se evidenció que la afluencia de pacientes a la Emergencia era
mayor en el sexo femenino, pero los procesos infecciosos afectaban por igual a ambos
sexos, el grupo de edad más afectado fue entre 50 y 60años. Los resultados de Proteína
C Reactiva no demostraron evidencia de desarrollar sepsis, sin embargo la Interleucina 6
y la Procalcitonina tuvieron valores elevados a su ingreso demostrando fuerte relación a
desarrollo de sepsis y complicaciones como estancia hospitalaria prolongada y muerte.
Se llegó a la conclusión de que tanto la Inteleucina 6 y Procalcitonina, solicitadas en
pacientes neutropénicos altamente sospechosos de desarrollar sepsis, ayudarán al médico
a determinar tratamiento antimicrobiano a emplear, sin esperar a dar las primeras líneas
usualmente recomendadas.
A major health problem, representing oncological diseases worldwide. The problem is evident in countries with limited by rising population and low socioeconomic level resources. It is estimated that cancer is the third or fourth cause of death in developing countries. The overall objective of this study is to evaluate the use of inflammatory markers as a prognostic factor in patients neurotropic Febrile Sepsis, who entered Emergency SOLCA in the period from 01/01/2015 to 12/31/2015, these patients had to meet certain clinical criteria. Scientific methodology was used and the method was descriptive, retrospective, Transversal non-experimental with a universe of 250 patients and a sample of 152. Among the results it was evident that the influx of patients to the emergency was greater in females, but infectious processes affecting equally to both sexes, the most affected age group was between 50 and 60años. The results of C-reactive protein showed no evidence of sepsis development; however interleukin 6 and Procalcitonin had high values on admission demonstrating strong relationship development of sepsis and complications such as prolonged hospital stay and death. It has been concluded that both Inteleucina 6 and Procalcitonin, requested in neutropenic patients discharged suspected of developing sepsis, help a doctor determine the antimicrobial treatment to use, without waiting to take the first lines usually recommended.
A major health problem, representing oncological diseases worldwide. The problem is evident in countries with limited by rising population and low socioeconomic level resources. It is estimated that cancer is the third or fourth cause of death in developing countries. The overall objective of this study is to evaluate the use of inflammatory markers as a prognostic factor in patients neurotropic Febrile Sepsis, who entered Emergency SOLCA in the period from 01/01/2015 to 12/31/2015, these patients had to meet certain clinical criteria. Scientific methodology was used and the method was descriptive, retrospective, Transversal non-experimental with a universe of 250 patients and a sample of 152. Among the results it was evident that the influx of patients to the emergency was greater in females, but infectious processes affecting equally to both sexes, the most affected age group was between 50 and 60años. The results of C-reactive protein showed no evidence of sepsis development; however interleukin 6 and Procalcitonin had high values on admission demonstrating strong relationship development of sepsis and complications such as prolonged hospital stay and death. It has been concluded that both Inteleucina 6 and Procalcitonin, requested in neutropenic patients discharged suspected of developing sepsis, help a doctor determine the antimicrobial treatment to use, without waiting to take the first lines usually recommended.
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Sepsis, Neutropenia febril, Epidemiología, Estudios retrospectivos, Hospital SOLCA de Guayaquil, Cantón Guayaquil, Ecuador, Polipéptido alfa relacionado con calcitonina