Estudio comparativo de la actividad nefroprotectora en extractos hidroalcoholicos de hojas y rizomas de Smilax purhampuy Ruiz
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2024
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Universidad de Guayaquil. Facultad de Ciencias Químicas
Resumen
La especie Smilax purhampuy Ruiz se ubica predominantemente en el cono sur de la Región Amazónica de Ecuador, a una altitud de 2500 metros sobre el nivel del mar. Esta planta es conocida por sus metabolitos secundarios, como antocianidinas, flavonoides y cumarinas, los cuales poseen un gran interés debido a sus propiedades antioxidantes, antiinflamatorias y efectos vasoprotectivos. El propósito fundamental de este proyecto fue evaluar la eficacia nefroprotectora de los extractos hidroalcohólicos de hojas y rizomas de Smilax purhampuy Ruiz. Este análisis se llevó a cabo mediante la medición de los niveles séricos de urea y creatinina en un modelo de nefrotoxicidad inducido por gentamicina (80 mg/kg) en ratas Wistar.
Los resultados revelaron un efecto nefroprotector de los extractos hidroalcohólicos de hojas y rizomas de S. purhampuy Ruiz, siendo este efecto concentración dependiente y alcanzando su máxima actividad a la dosis de 400 mg/kg. Además, se observó que el extracto de hojas exhibió una mayor actividad nefroprotectora en comparación con el extracto de rizomas.
The species Smilax purhampuy Ruiz is predominantly found in the southern cone of the Amazon Region in Ecuador, at an altitude of 2500 meters above sea level. This plant is known for its secondary metabolites, such as anthocyanidins, flavonoids, and coumarins, which are of great interest due to their antioxidant, anti-inflammatory, and vasoprotective properties. The main purpose of this project was to evaluate the nephroprotective efficacy of hydroalcoholic extracts from leaves and rhizomes of Smilax purhampuy Ruiz. This analysis was conducted by measuring serum levels of urea and creatinine in a gentamicin- induced nephrotoxicity model (80 mg/kg) in Wistar rats. The results revealed a nephroprotective effect of hydroalcoholic extracts from leaves and rhizomes of S. purhampuy Ruiz, with this effect being concentration- dependent and reaching its maximum activity at a dose of 400 mg/kg. Furthermore, it was observed that the leaf extract exhibited greater nephroprotective activity compared to the rhizome extract.
The species Smilax purhampuy Ruiz is predominantly found in the southern cone of the Amazon Region in Ecuador, at an altitude of 2500 meters above sea level. This plant is known for its secondary metabolites, such as anthocyanidins, flavonoids, and coumarins, which are of great interest due to their antioxidant, anti-inflammatory, and vasoprotective properties. The main purpose of this project was to evaluate the nephroprotective efficacy of hydroalcoholic extracts from leaves and rhizomes of Smilax purhampuy Ruiz. This analysis was conducted by measuring serum levels of urea and creatinine in a gentamicin- induced nephrotoxicity model (80 mg/kg) in Wistar rats. The results revealed a nephroprotective effect of hydroalcoholic extracts from leaves and rhizomes of S. purhampuy Ruiz, with this effect being concentration- dependent and reaching its maximum activity at a dose of 400 mg/kg. Furthermore, it was observed that the leaf extract exhibited greater nephroprotective activity compared to the rhizome extract.
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SMILAX PURHAMPUY R, NEFROTOXICIDAD, EXTRACTO HIDROALCOHÓLICO, GENTAMICINA