Efecto de la actividad antibacteriana del aceite esencial de Eucalyptus globulus L. en sistemas de liberación prolongada
Fecha
2018
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Universidad de Guayaquil. Facultad de Ciencias Químicas
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En el presente trabajo de investigación se realiza el estudio del efecto antibacteriano del aceite esencial de Eucalyptus globulus Labill en sistemas de liberación prologada. Se desarrolló un diagrama de fases para la obtención de sistemas ternarios a base de Tween-80, aceite esencial de Eucalyptus globulus L. y agua destilada, en el cual se logró identificar las regiones en donde se formaron las nanoestructuras (microemulsiones y cristales líquidos). Dichos sistemas se caracterizaron mediante un estudio de estabilidad (apariencia, color y pH) y microscopía de luz polarizada. Fue posible incorporar de 5 a 50 mg de sulfametoxazol en las microemulsiones (ME). Finalmente se determinó la actividad antibacteriana de los sistemas ME 24, ME 24 *, ME 26 y ME 26 * frente a dos cepas: Escherichia coli y Staphylococcus aureus, de los cuales ME 24* presentó un halo de inhibición de 16±1 mm y ME 24 22±1 mm respectivamente. Ambos resultados superan incluso los valores del control positivo (sulfametoxazol). El presente trabajo constituye el primer reporte de la potencial actividad antibacteriana de las microemulsiones en estudio
In the present project of investigation the study of the antibacterial effect of the essential oil of Eucalyptus globulus Labill is carried out in systems of prolonged reléase. A phase diagram was developed to obtain ternary systems based on Tween-80, essential oil of Eucalyptus globulus L. and distilled water, in which it was possible to identify the regions where the nanostructures were formed (microemulsions and liquid crystals). These systems were characterized by a stability study (appearance, color and pH) and polarized light microscopy. It was possible to incorporate 5 to 50 mg of sulfamethoxazole into the microemulsions (ME). Finally, the antibacterial activity of the ME 24, ME 24 *, ME 26 and ME 26 * systems was determined against two strains: Escherichia coli and Staphylococcus aureus, of which ME 24 * presented an inhibition halo of 16±1 mm and ME 24 22±1 mm respectively. Both results exceed even the values of the positive control (sulfamethoxazole). The present work constitutes the first report of the potential antibacterial activity of the microemulsions under study
In the present project of investigation the study of the antibacterial effect of the essential oil of Eucalyptus globulus Labill is carried out in systems of prolonged reléase. A phase diagram was developed to obtain ternary systems based on Tween-80, essential oil of Eucalyptus globulus L. and distilled water, in which it was possible to identify the regions where the nanostructures were formed (microemulsions and liquid crystals). These systems were characterized by a stability study (appearance, color and pH) and polarized light microscopy. It was possible to incorporate 5 to 50 mg of sulfamethoxazole into the microemulsions (ME). Finally, the antibacterial activity of the ME 24, ME 24 *, ME 26 and ME 26 * systems was determined against two strains: Escherichia coli and Staphylococcus aureus, of which ME 24 * presented an inhibition halo of 16±1 mm and ME 24 22±1 mm respectively. Both results exceed even the values of the positive control (sulfamethoxazole). The present work constitutes the first report of the potential antibacterial activity of the microemulsions under study
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EUCALYPTUS GLOBULUS LABILL, SISTEMAS NANOESTRUCTURADOS, MICROEMULSIONES, ACTIVIDAD ANTIBACTERIANA